NFL odds: Week 2 parlays featuring favorites, underdogs include Giants vs. Rams, Jaguars vs. Broncos

Week 2 of the 2026 NFL season begins on Thursday, Sept. 17, with Thursday Night Football featuring the Detroit Lions and Buffalo Bills. There were plenty of surprising results in Week 1, and even though bettors might be leaning towards conventional wisdom for Week 2,

Bills vs Lions spread predictions, odds for NFL Week 2 Thursday Night Football

The Buffalo Bills host the Detroit Lions at Highmark Stadium on Sept. 17 and USA TODAY's NFL experts have locked in their picks against the spread for the action.

Kalshi Referral Code CLEVELAND: New $25 NFL for Week 2; plus, Lions-Bills live odds update

The Kalshi promo code CLEVELAND has been updated for Lions vs. Bills live odds and Sunday’s Bengals and Browns games: deposit $25, get $25, and trade $50 across Kalshi's NFL markets, plus how to redeem it.

NFL Week 2 odds, picks: Jets continue to stay frisky, while Baker Mayfield torches former Browns team

As we turn our attention to the upcoming slate, we're somewhat going back to the well with a couple of teams, attacking the Browns and buying the Jets with the points.

NFL futures week 2: Caleb Williams takes a leap in the way-too-early MVP picture

NFL Week 2 futures betting report.